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A Need for Authenticity

admin — Wed, 26 Mar 2008 12:03:56 +0000

My old high-school classmate Fred, for example, confided that he’d tried Viagra to celebrate his fortieth birthday and couldn’t believe what a difference it had made when he and his girlfriend had sex that night. Yet despite having had a wonderful night of lovemaking, Fred announced, “I won’t lake it again.”
“Why not!” I asked,
“It’s too hard to live up to!” he said, and we both laughed at his unintentional pun. Then Fred grew serious. “I don’t want to be in a situation,” he said. “where my girlfriend comes to expect that my penis will be completely firm on command, It would be too much pressure for me. I’m okay the way I am, and I don’t want to feel that I need to take a pill in order to make love.”
I thought this was an eminently sensible response. Creating an artificial new level ot erectile performance is not the best way to sustain an authentic relationship. Fred wanted to be accepted for who he was, without any drug enhancement. But as we shall see, this kind of mature altitude is by no means universal among perfectly healthy man in teir quest for sexual prowess.

The Viagra Six-Pack

admin — Wed, 26 Mar 2008 11:38:28 +0000

The ability to have a really firm erection is important to men, especially those who are not yet in a committed relationship and hope to impress a partner with their sexual prowess. Women sometimes laugh at what they see as the simplicity of men. “Why do guys think sex is all about the penis.’” they ask. For men, sexual performance corresponds with self-esteem, and with the typical male focus, on the penis, greater hardness and rigidity translates into greater performance.
The Viagra Myth plays easily into this mind-set because the word on the street is that Viagra does indeed make a normal erection even firmer. As a physician, I am reluctant to prescribe Viagra to anyone who doesn’t truly need it to erectile dysfunction, but I have had many patients and even friends with normal elections who have shared their Viagra stories with me.

The Viagra Edge. Is Harder Better?

admin — Wed, 26 Mar 2008 11:27:23 +0000

What about men who do not have a true erection problem? Just like the young students at Harvard Medical School who ask me what Viagra can do for them, many men who don’t have any actual problems wirh normal potency have also wondered whether Viagra might turbocharge their penis, transforming them into the sexual superstar of their fantasies.

Here is another element ol the Viagra Myth has pervaded our culture! many young men, nervous or insecure about their sexual prowess and performance, assume that having a guaranteed superhard penis is the ultimate path to happiness. Is this true! Does Viagra actually increase rigidity for men without erection problems! And does an extra-hard penis really reward the man who already functions normally, even if this requires a drug to help him accomplish such a goal? Or is this another Faustian bargain with i profound but hidden cost to pay further down the road?

Sildenafil Citrate. Clinical trials

admin — Sun, 23 Mar 2008 16:27:13 +0000

Sildenafil citrate has been evaluated clinically and experimentally with each of these endpoint measurements . Initial studies using the GAQ in more than 3000 patients with a variety of etiologies of ED in I1 double-blind , placebo-con- trolled , flexible-dose studies at week 12 demonstrated that placebo improved erections by 22 % compared with sildenafil at 76 %. When querying patients about successful attempts at intercourse , this same group of patients answered 26 % of the questions positively with placebo compared with 66 % with silde- nafil . In reviewing four randomized , double-blind , placebo-controlled , fixed- dose studies of 12-24 weeks duration , a placebo response was demonstrated in the group of patients queried about improvement in their erections with GAQ . In this group , 24 % had positive placebo response , 63 % responded positively to 25 mg of sildenafil , 74 % to 50 mg , and 82 % to 100 mg . When observing patients of various ages , similar efficacies were demonstrated . In these studies , 24 % of patients who were younger than 60 years of age respond- ed to placebo compared with 78 % of those of the same age in the sildenafil group ( P < . 0001 ); 18 % of patients responded to placebo compared with 69 % to sildenafil ( P < . 0001 ).

(more…)

Sildenafil Citrate. Clinical trial outcome measurement

admin — Sun, 23 Mar 2008 16:12:39 +0000

The clinical efficacy of erectogenic agents can be measured with a variety of instruments . The most common instrument is the global efficacy assessment question ( GAQ ), which asks patients ” Did the treatment that you used for your erections improve your erections during the time of therapy “. Although this is an important endpoint measure , it is not as rigorous as some other measures . However , it is the standard measurement for most clinical studies of erectile function agents . Other endpoints include a measurement of the percent of suc- cessful attempts at intercourse and a measurement of the International Index of Erectile Function ( LIEF ) with changes in the erectile function domain score from baseline to study completion . Using this score , values less than 10 sug- gest severe ED and values higher than 26 suggest normal erectile function . Other methods used for measurement include sexual encounter profile ques- tions ( SEP ). The SEP-2 asks , ” Were you able to insert your penis into your partner ‘ s vagina ” and the SEP-3 asks , ” Did your erections last long enough to have successful intercourse ?”

Sildenafil citrate : a 5-year update on the worldwide treatment of 20 million men with erectile dysfunction

admin — Sun, 23 Mar 2008 15:26:54 +0000

Culley C . Carson III

Introduction

Erectile dysfunction ( ED ) is a highly prevalent condition affecting as many as 50 % of men 40 years of age or older . ED , defined as ” the inability to obtain and maintain erections sufficiently to allow sexual intercourse “, has been widely studied for many decades . The first breakthrough in effective , minimally inva- sive , safe treatment was the establishment of the oral agent sildenafil citrate for the treatment of ED . ED can be caused by systemic diseases , especially those effecting the vascular system or nervous system and can be associated with pri- mary or secondary psychologic complaints . The incidence and prevalence of ED increases with age , with the incidence doubling with each decade of life after the age of 50 . As men age , conditions of aging appear and medications for treating these chronic conditions are used widely . Many of the medications used to treat chronic conditions such as diabetes , hypercholesterolemia , renal disease , and depression will exacerbate ED . The most common culprits for medically-induced ED are antihypertensive drugs and antidepressants . Pelvic surgery and radiation therapy for conditions of aging such as prostate cancer and colon cancer may also produce ED . Life style conditions , such as cigarette smoking , obesity , sedentary life style , and the metabolic syndrome are also associated with ED .

Sildenafil

Sildenafil citrate ( Viagra , Pfizer , New York ) was first introduced to the US mar- ket in April 1998 . During the past five years , more than 20 million men world- wide have been treated with Viagra , with more than 10 million men in the US alone . More than 24 million prescriptions have been dispensed . This accounts for more than 100 million prescriptions worldwide , including 700 million tablets . It has been estimated that 8 . 6 sildenafil tablets are dispensed every sec- ond worldwide . More than 500 , 000 physicians are prescribing sildenafil ; it has been approved , widely used , and accepted in more than 110 countries.

Advantages of Generic Drugs

admin — Tue, 18 Mar 2008 23:13:56 +0000

All medicines are identified by two names. One is the generic name or the chemical name. And the other is the marketing name or the brand name. A generic is a medication often recognized by its chemical name.

Why not brand drug and why generic?

Generic drugs have all the active elements of a brand name drug. But still you get it at reasonable rates. The pharmaceuticals that produce these drugs don’t have to spend money on research, advertising or even marketing the drugs. So there is no extra cost involved while selling these generic drugs. And it comes to you at a very reasonable rates. Generic drugs are as much as 70% cheaper than their brand name drug.
Generic drug is less expensive.
Generic drugs, as effective as brand-name drugs.

Makers of Generic medicines must prove their drug quality to get an approval. It should be:

Safe as brand name drugs.
Made under proper manufacturing laws.
Includes the same ingredients but can vary in color, shape etc.

Since generic drugs are made under strict regulations, it is as safe and effective as brand name drugs.

Generic drugs, similar in strength.

It has the same therapeutic effect as that of brand name drug.
Both drugs are similar in its strength.
Their effectiveness lasts for the same period.
It’s similar in dosage and administration.

Who makes Generic drugs?

Some times, companies who make brand name drugs engage themselves in making generic drugs as well. Because of its growing popularity, pharmacies sell two versions of the same drug. The first one using the expensive brand name and the second one using the generic name. Some drug companies only make generic drugs. No matter who makes them, these drugs should meet the standards before it is brought out into the market.

Price: It is the vital element, which helps sell generic drugs. When you get the same effect of a drug, meeting all the essential standards, in a much low priced drug, you wouldn’t want to waste a penny. That’s why generic drugs have flooded the world drug market and its popularity is increasing with each passing day. Today, you will not find a generic drug for all brand name drugs. But, with more and more people reaching out for generic drugs, it’s certain that pharmaceutical companies will come forward to help us lead a better ‘less expensive life’.